•Trouble concentrating, remembering details, and making decisions

•Fatigue

•Feelings of guilt, worthlessness, and helplessness

•Pessimism and hopelessness

•Insomnia, early-morning wakefulness, or sleeping too much

•Crankiness or irritability

•Restlessness

•Loss of interest in things once pleasurable, including sex

•Overeating, or appetite loss

•Aches, pains, headaches, or cramps that won't go away

•Digestive problems that don't get better, even with treatment

•Persistent sad, anxious, or "empty" feelings

•Suicidal thoughts or suicide attempts